In-Situ Synthesis Of 3d Cu2o@Cu-Based Mof Nanobelt Arrays With Improved Conductivity For Sensitive Photoelectrochemical Detection Of Vascular Endothelial Growth Factor 165

Construction of novel photoelectrochemical (PEC) materials with unique structures can effectively improve the photoelectric conversion efficiency. Here, a self-supported Cu2O@Cu-MOF/copper mesh (CM) nanobelt arrays with high specific surface area, high orientation, and high photoelectric conversion performance is obtained by in-situ grown strategy. Such PEC aptasensor is constructed based on the Cu2O@Cu-M0F/CM combined with rolling circle amplification and enzymatic biocatalytic precipitation for vascular endothelial growth factor 165 analysis. This strategy achieves excellent cooperative signal amplification, which greatly improves the detection sensitivity. The PEC aptasensor exhibited a wide calibration ranged from 10 to 1 x 10(8) fM with a detection limit down to 2.3 fM (S/N = 3). The construction of semiconductor@MOFs has developed the potential application of MOFs in photoelectrochemical and found a reliable path for ultrasensitive detection of biomarkers.