Post-TBI splenectomy may exacerbate coagulopathy and platelet activation in a murine model.

Mackenzie C Morris,Devin John,Kathleen E Singer,Ryan Moran,Emily McGlone,Rosalie Veile,Holly S Goetzman,Amy T Makley,Charles C Caldwell,Michael D Goodman

Thrombosis Research（2020）

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摘要

•Traumatic brain injury (TBI) is associated with a subacute, hypercoagulable state.•Previous research shows TBI with concomitant splenectomy to have an increased mortality.•A murine model was used to investigate coagulation and platelet activation.•TBI + splenectomy induced an acute hypocoagulable state.•TBI + splenectomy induced subacute hypercoagulability and increased platelet activation.

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关键词

Traumatic brain injury,Splenectomy,Coagulopathy,Platelets,Rotational thromboelastometry

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