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Intergroup Randomized Phase III Study of Postoperative Oxaliplatin, 5 Fluorouracil, and Leucovorin Versus Oxaliplatin, 5 Fluorouracil, Leucovorin, and Bevacizumab for Patients …

A Bapsi Chakravarthy,Fengmin Zhao,Neal J Meropol,Patrick J Flynn,Lynne I Wagner,Jeffrey Sloan,Robert B Diasio,Edith P Mitchell,Paul Catalano,Bruce J Giantonio,Robert B Catalano,Daniel G Haller, Rashid A Awan,Mary F Mulcahy,Timothy E O'Brien, Roger Santala,Christine Cripps,John R Weis,James N Atkins,Cynthia G Leichman,Nicholas J Petrelli,Frank A Sinicrope,James D Brierley,Joel E Tepper,Peter J O'Dwyer,Elin R Sigurdson,Stanley R Hamilton,David Cella,Al B Benson

Oncologist（2019）

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Abstract
BackgroundThe addition of bevacizumab to chemotherapy improved outcomes for patients with metastatic colon cancer. E5204 was designed to test whether the addition of bevacizumab to mFOLFOX6, following neoadjuvant chemoradiation and definitive surgery, could improve overall survival (OS) in patients with stage II/III adenocarcinoma of the rectum.
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