Plastic changes in the brain after human hand allotransplantation.

Vascularized composite allotransplantation of the hand is technically feasible and is the only option to recover a lost hand after amputation. However, universal acceptance of this surgical reconstruction as a medical standard of care has not been achieved for the uncertainty of outcome after surgery.(1)We performed an exploratory study to examine the neurophysiologic changes in the somatosensory and primary motor cortices after hand transplant.