Construction And Research On Size And Phase 'Fixed-Point Remodelling' Intelligent Drug Delivery System

It is important to enhance penetration depth of nanomedicine and realise rapid drug release simultaneously at targeted tumour for improving anti-tumour efficiency of chemotherapeutic drugs. This project employed sodium alginate (Alg) as matrix material, to establish tumour-responsive nanogels with particle size conversion and drug controlled release functions. Specifically, tumour-targeting peptide CRGDK was conjugated with Alg first (CRGDK-Alg). Then, doxorubicin (DOX) was efficiently encapsulated in CRGDK-FeAlg nanogel during the cross-linking process (CRGDK-FeAlg/DOX). This system was closed during circulation. Once reaching tumour, the particle size of nanogels was reduced to similar to 25 nm, which facilitated deep penetration of DOX in tumour tissues. After entering tumour cells, the size of nanogels was further reduced to similar to 10 nm and DOX was released simultaneously. Meanwhile, FeAlg efficiently catalysed H(2)O(2)to produce center dot OH by Fenton reaction, achieving local chemodynamic therapy without O(2)mediation. Results showed CRGDK-FeAlg/DOX significantly inhibited tumour proliferationin vivowithV/V0 of 1.13 after treatment, significantly lower than that of control group withV/V0 of 4.79.