From dysregulated microRNAs to structural alterations in the striatal region of METH-injected rats.

Hossein Chavoshi,Mahdi Eskandarian Boroujeni,Mohammad-Amin Abdollahifar,Abdollah Amini,Ava Modirzadeh Tehrani,Meysam Hassani Moghaddam,Mohsen Norozian,Reza Mastery Farahani,Abbas Aliaghaei

Journal of Chemical Neuroanatomy（2020）

引用 13|浏览8

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摘要

•METH injection induced considerable impairment in motor coordination and muscle activities.•METH provoked astrocyte over-activation (astogliosis) in the striatum.•METH exacerbated the striatal atrophy.•MiRNA sequencing analysis identified 167 differentially expressed miRNAs in the striatum under METH treatment.•The pathway enrichment analysis revealed remarkably enriched pathways mainly involved in cell apoptosis, growth and synaptic plasticity

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关键词

Methamphetamine,Striatum,Neurotoxicity,miRNA expression profiling

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