Impaired LTD-like motor cortical plasticity in female patients with major depression disorder

Chang Yu,Ang Li,Xingxing Li,Zan Chen,Pingjie Wang,Zhifang Dong,Zafiris J. Daskalakis,Dongsheng Zhou

Neuropharmacology（2020）

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摘要

•Our results revealed persistent LTD-like plasticity deficits in female patients with depression.•LTD-like plasticity was impaired in MDD despite the fact that BDNF were comparable to that of healthy subjects.•Impaired LTD-like plasticity may an important mechanism linked to the pathophysiology and treatment of this disorder.

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关键词

Depression,Cortical plasticity,Motor learning,Human,BDNF,cTBS

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