A versatile strategy to synthesize N-methyl-anthranilic acid-labelled glycoprobes for fluorescence-based screening assays.
CHEMICAL COMMUNICATIONS(2020)
Abstract
Here we propose a general strategy to label carbohydrates withN-methyl-anthranilic acid at the anomeric position. Through two examples, we demonstrate that the generated glycoprobes are suitable for fluorescence-based binding/competition assays. Our approach is expected to readily generate series of glycoprobes dedicated to screening assays for the discovery of drugs targeting carbohydrate-protein interactions.
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Key words
glycoprobes,screening assays,n-methyl-anthranilic,acid-labelled,fluorescence-based
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