Development and validation of an oxidative phosphorylation-related gene signature in lung adenocarcinoma

Aim:To develop an oxidative phosphorylation (OXPHOS)-related gene signature of lung adenocarcinoma (LUAD).Materials & methods:We split The Cancer Genome Atlas LUAD cohort into a training set and a test set; we used the least absolute shrinkage and selection operator Cox method to structure the OXPHOS-related prognostic signature in the training set and verified in the test set and GSE30219 dataset. Meanwhile, the diagnostic model was constructed using the logistic Cox method.Results:The signature consisted of seven genes (LDHA,CFTR,HSPD1,SNHG3,MAP1LC3C,COX6B2, andTWIST1). LUAD patients were divided into high- and low-risk groups, demonstrating good diagnostic and prognostic capabilities.Conclusion:We developed the first-ever OXPHOS-related signature with both prognostic predictive power and diagnostic efficacy.