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A Single Immunization with Nucleoside-Modified Mrna Vaccines Elicits Strong Cellular and Humoral Immune Responses Against SARS-CoV-2 in Mice

Dorottya Laczko,Michael J. Hogan,Sushila A. Toulmin,Philip Hicks,Katlyn Lederer,Brian T. Gaudette,Diana Castano,Fatima Amanat,Hiromi Muramatsu,Thomas H. Oguin,Amrita Ojha,Lizhou Zhang,Zekun Mu,Robert Parks,Tomaz B. Manzoni,Brianne Roper,Shirin Strohmeier,Istvan Tombacz,Leslee Arwood,Raffael Nachbagauer,Katalin Kariko,Jack Greenhouse,Laurent Pessaint,Maciel Porto, Tammy Putman-Taylor,Amanda Strasbaugh,Tracey-Ann Campbell,Paulo J. C. Lin,Ying K. Tam,Gregory D. Sempowski,Michael Farzan,Hyeryun Choe,Kevin O. Saunders,Barton F. Haynes,Hanne Andersen,Laurence C. Eisenlohr,Drew Weissman,Florian Krammer,Paul Bates,David Allman,Michela Locci,Norbert Pardi

Immunity（2020）

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关键词
SARS-CoV-2,COVID-19,mRNA vaccine,nucleoside-modified mRNA,mRNA-LNP
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