ZD2‐Engineered Gold Nanostar@Metal‐Organic Framework Nanoprobes for T1‐Weighted Magnetic Resonance Imaging and Photothermal Therapy Specifically …

Compared with other subtypes of breast cancer, triple‐negative breast cancer (TNBC) is seriously threatening to human life. Therefore, it is a matter of urgency to develop multifunctional nanoprobes for visualized theranostics of TNBC, achieving specific targeting toward only TNBC, but not other subtypes. Nanoscale metal–organic frameworks (MOFs) show important potential in visualized theranostics of tumors, but it is critical to synthesize well‐defined core–shell MOF‐based nanocomposites by encapsulating a single nanoparticle within MOF. In this study, a TNBC‐targeted peptide (ZD2)‐engineered, and a single gold nanostar (AuNS) coated within MIL‐101‐NH2(Fe) by coating MOF with four cycles, obtain well‐defined core–shell AuNS@MOF‐ZD2 nanocomposites, which are expected to achieve T1‐weighted magnetic resonance imaging and photothermal therapy (PTT) specifically targeting toward TNBC. The …