Peri-arterial pathways for clearance of α-Synuclein and tau from the brain: Implications for the pathogenesis of dementias and for immunotherapy.

Jacqui Nimmo,David A Johnston, J C Dodart,Matthew T MacGregor-Sharp,Roy O Weller,James A R Nicoll,Ajay Verma,Roxana O Carare

Alzheimer's & dementia (Amsterdam, Netherlands)（2020）

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摘要

Age-related failure of IPAD may play a role in the pathogenesis of synucleinopathies and tauopathies. αSyn persists within IPAD at 24 hours, which may affect immunotherapy for αSyn.

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关键词

IPAD,Immunotherapy,perivascular drainage,tau,α‐synuclein

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