Strain Differences in Responsiveness to Repeated Restraint Stress Affect Remote Contextual Fear Memory and Blood Transcriptomics

•Fear memory is strain dependent; greater in the less stress-reactive strain.•Repeated stress attenuates remote fear memory, but only in the less stress-reactive strain.•Strain neutral, stress-responsive genes are putative blood-based stress biomarkers.•Strain-specific stress-responsive genes are putative blood markers of vulnerability to stress.