Strain Differences in Responsiveness to Repeated Restraint Stress Affect Remote Contextual Fear Memory and Blood Transcriptomics
Neuroscience(2020)
Abstract
•Fear memory is strain dependent; greater in the less stress-reactive strain.•Repeated stress attenuates remote fear memory, but only in the less stress-reactive strain.•Strain neutral, stress-responsive genes are putative blood-based stress biomarkers.•Strain-specific stress-responsive genes are putative blood markers of vulnerability to stress.
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Key words
CFC,CRS,DEGs,EPM,F344,NS,PTSD,WKY
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