Cellular poly(C) binding protein 2 interacts with porcine epidemic diarrhea virus papain-like protease 1 and supports viral replication.

Pengfei Zhang,Linyang Yu,Jianguo Dong,Yanling Liu,Leyi Zhang,Pengshuai Liang,Lei Wang,Bin Chen,Li Huang,Changxu Song

Veterinary Microbiology（2020）

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摘要

•PLP1 promotes PEDV replication and inhibits expression of TNF-α induced IFN-β.•PLP1 interacts with cellular PCBP2.•PCBP2 expression affects PEDV replication.•The interaction of PCBP2 and PLP1 supports PEDV replication.

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关键词

PEDV,Coronavirus,Papain-like proteases,Poly(C) binding protein 2,Virus replication,Interaction

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