Igm, Iga And Igg Response To Conjugate Polysaccharides In Children With Recurrent Respiratory Infections

Recurrent respiratory tract infections (rRTI) in children represent a challenge in physician's practice and raise the suspicion of an immunological defect, when allergy and other chronic respiratory diseases are excluded [1]. When major primary antibody deficiencies are excluded [2-4], the diagnosis of Unclassified Primary Antibody Deficiency (UnPAD) or a Specific Antibody Deficiency (SAD) due to a reduced response to purified or conjugate pneumococcal polysaccharide vaccine (PPV-SAD and PCV-SAD, respectively) should be considered [5].