Quantification Of Skin Sensitivity To Ultraviolet Radiation Using Ultrawideband Optoacoustic Mesoscopy
BRITISH JOURNAL OF DERMATOLOGY(2021)
Abstract
Phototesting is used to assess individual sensitivity to ultraviolet (UV) radiation in order to determine adequate UV dosage for phototherapy . In the standard procedure, small skin areas are exposed to increasing doses of UV radiation. The lowest UV dose that induces a delineated erythema at 24±2 h after UV exposure defines the minimal erythema dose (MED) . Visual assessment is the gold standard for MED determination; however, it is prone to observer variability . Optical methods have been considered to quantify the magnitude of erythema response. However, they are limited by light scattering therefore high-resolution is restricted to depths of <200 μm resulting in unreliable measurements .
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