The Relationship between HDAC3 and Malignant Tumors: A Mini Review.
CRITICAL REVIEWS IN EUKARYOTIC GENE EXPRESSION（2020）
Abstract
Histone deacetylases 3 (HDAC3) is a member of the histone deacetylases family. This family is associated with cellular physiological function, such as signal transduction, cell cycle, proliferation, apoptosis, and cardiac devel-opment. HDAC3 plays an important role in the progression of malignant tumors, especially in terms of proliferation, apoptosis, metastasis, angiogenesis, and anticancer drug resistance. This review discusses the basic elements of HDAC3 and the relationship between HDAC3 and malignant tumors.
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Key words
histone deacetylases,HDAC3,malignant tumors,proliferation,apoptosis,metastasis,angiogenesis,anticancer drug resistance
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