Obesity impacts brain metabolism and structure independently of amyloid and tau pathology in healthy elderly
Alzheimer's & dementia (Amsterdam, Netherlands)(2020)
摘要
Aims/hypothesisMidlife obesity is a risk factor for dementia. We investigated the impact of obesity on brain structure, metabolism, and cerebrospinal fluid (CSF) core Alzheimer's disease (AD) biomarkers in healthy elderly. MethodsWe selected controls from ADNI2 with CSF AD biomarkers and/or fluorodeoxyglucose positron emission tomography (FDG-PET) and 3T-MRI. We measured cortical thickness, FDG uptake, and CSF amyloid beta (A beta)1-42, p-tau, and t-tau levels. We performed regression analyses between these biomarkers and body mass index (BMI). ResultsWe included 201 individuals (mean age 73.5 years, mean BMI 27.4 kg/m(2)). Higher BMI was related to less cortical thickness and higher metabolism in brain areas typically not involved in AD (family-wise error [FWE] <0.05), but not to AD CSF biomarkers. It is notable that the impact of obesity on brain metabolism and structure was also found in amyloid negative individuals. Conclusions/interpretationIn the cognitively unimpaired elderly, obesity has differential effects on brain metabolism and structure independent of an underlying AD pathophysiology.
更多查看译文
关键词
body mass index,cerebrospinal fluid Alzheimer's disease biomarkers,fluorodeoxyglucose PET,magnetic resonance imaging,obesity,pre-clinical Alzheimer's disease
AI 理解论文
溯源树
样例
![](https://originalfileserver.aminer.cn/sys/aminer/pubs/mrt_preview.jpeg)
生成溯源树,研究论文发展脉络
Chat Paper
正在生成论文摘要