Injection of minocycline into the periaqueductal gray attenuates morphine withdrawal signs

Qiaofeng Liu, Shan Tang,Xiaoyu Du,Yuzhu Sun, Jialing Lai,Xin Wang

Neuroscience Letters（2020）

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摘要

•Morphine withdrawal activates microglia in midbrain periaqueductal gray.•Minocycline suppresses microglia activation and morphine withdrawal signs.•Minocycline suppresses morphine withdrawal signs by inhibiting microglia activation and downregulation of pannexin-1 and p-mTOR expression.

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关键词

Morphine withdrawal,panx1,p-mTOR,PKA,Minocycline,Midbrain periaqueductal gray

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