Topical 'dual-soft' glucocorticoid receptor agonist for dermatology.

Kevin N Dack,Patrick S Johnson,Krister Henriksson,Stefan Eirefelt,Martin A Carnerup,Martin Stahlhut, Anna K Ollerstam

Bioorganic & Medicinal Chemistry Letters（2020）

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摘要

Steroidal glucocorticoids (GR agonists) have been widely used for the topical treatment of skin disorders, including atopic dermatitis. They are a very effective therapy, but they are associated with both unwanted local effects in the skin (skin thinning/atrophy) and systemic side effects. These effects can limit the long-term utility of potent steroids.

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关键词

Dermatology,Non-steroidal,SEGRA,Soft-drug,Glucocorticoid receptor agonist

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