MicroRNA-342-3p is a potent tumour suppressor in hepatocellular carcinoma

Ronja-Melinda Komoll,Qingluan Hu,Olaniyi Olarewaju, Lena von Döhlen,Qinggong Yuan, Yu Xie,Hsin-Chieh Tsay, Joel Daon,Renyi Qin,Michael P Manns,Amar Deep Sharma,Andrei Goga,Michael Ott,Asha Balakrishnan

Journal of Hepatology（2021）

引用 98|浏览37

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摘要

•Distinct global microRNA landscape in regressing liver tumours compared with tumours.•Identification and validation of miR-342-3p as a tumour suppressor in HCCs.•MiR-342-3p significantly attenuates tumour development in 3 mouse models of HCC.•MiR-342-3p prolongs survival of LT2/MYC and LT2/RAS mice with liver tumours.•MiR-342-3p plays a role in metabolic reprogramming in HCC, by targeting MCT1.

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关键词

Hepatocellular carcinoma,Liver cancer,MicroRNAs,Tumour regression,MYC,RAS,MCT1,Lactate transport,Tumour metabolism

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