Topical nanostructured lipid carrier gel of quercetin and resveratrol: Formulation, optimization, in vitro and ex vivo study for the treatment of skin cancer

•Optimization and preparation of QCT & RSV loaded NLCs for the treatment of skin cancer.•Synergistic actions over the use of single drugs in skin cancer treatment through targeting of multiple molecular pathways.•Improved drug accumulation in dermal layers.•Improved cytotoxic and anti-metastatic effects.