Effects of AS2819899, a novel selective PI3Kδ inhibitor, in a NZB/W F1 mouse lupus-like nephritis model

Yoko Kaneko,Hidehiko Fukahori,Kaoru Yamagami,Tomoko Kawashima,Misato Ito,Masahiko Akamatsu,Takanori Marui,Koji Kato,Fumie Takahashi,Tatsuaki Morokata

International Immunopharmacology（2020）

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摘要

•AS2819899 is a newly synthesized PI3Kδ selective inhibitor.•AS2819899 suppressed B cell activation in vitro.•AS2819899 suppressed antibody production in vivo mouse models.•AS2819899 prevented worsening of kidney function in lupus-prone mouse model.•We identified useful pharmacodynamics marker of PI3Kδ inhibitor.

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关键词

PI3Kδ,Antibody production,Lupus nephritis,NZB/W F1,Pharmacodynamics

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