Genotype Distribution of CNDP1 Polymorphisms in the Healthy Chinese Han Population: Association with HbA1c and Fasting Blood Glucose

We have previously reported that theCNDP1(CTG)(5)allele affords protection against diabetic nephropathy (DN) in patients with Type 2 diabetes (T2DM) of Caucasian origin. Because the incidence of ESRD attributable to both Type 1 diabetes (T1DM) and T2DM is higher among South Asian than Caucasian people, the present study assessed relevantCNDP1polymorphisms and their association with metabolic parameters in the Chinese Han population. To this end, the (CTG)(n)allele distribution along with 5 relevant SNPs in theCNDP1gene, previously reported to be associated with DN in non (CTG)(5)carriers of Afro-American ethnicity, were determined in 663 healthy individuals. The (CTG)(6)homozygous genotype was the most prevalent (84.5%) genotype in the Chinese Han population. The (CTG)(5)and (CTG)(4)alleles were present in a small minority of individuals accounting for 15.2% and 0.3% of genotypes with at least one (CTG)(5)or one (CTG)(4)allele, respectively. Only 0.5% of individuals carried the homozygous (CTG)(5)genotype and individuals carrying the homozygous (CTG)(4)genotype were not found. The minor allele frequencies (MAFs) of the 5 SNP were 0.197 (C allele for rs4892247), 0.0855 (C allele for rs62099905), 0.085 (G allele for rs62099906), 0.066 (T allele for rs62099907), and 0.18 (A allele for rs72979715). All the SNPs except rs4892247 genotypes were in the Hardy-Weinberg equilibrium. Neither the (CTG)(n)polymorphism nor the latter three SNPs reached significance when compared with different metabolic parameters. In contrast, individuals with the TT genotype of rs62099905 presented lower fasting blood glucose but higher HbA1c levels. In conclusion, the rs62099905 in theCNDP1gene is associated with serum glucose levels in the healthy Chinese Han population, while for theCNDP1(CTG)(n)polymorphism, no association with serological parameters was found.