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UPLC-MS-based urine nontargeted metabolic profiling identifies dysregulation of pantothenate and CoA biosynthesis pathway in diabetic kidney disease

Tao Ma,Tonghua Liu,Peifeng Xie,Sheng Jiang,Wenming Yi,Pei Dai,Xiangyu Guo

Life Sciences（2020）

Cited 41|Views31
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Abstract
•Four metabolites in pantothenate and CoA biosynthesis pathway were significantly down regulated in DKD patients.•Pantothenate and its related metabolites have the potential to be a promising biomarker for predicting DKD.•PA and CoA biosynthesis pathway can be potential therapeutic targets for DKD treatment.
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Key words
Type 2 diabetes,Diabetic kidney disease,Metabolomics,Urine,Pantothenate and CoA,Pantothenic acid
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