Enhancement of Soft Tissue Sarcoma Response to Gemcitabine through Timed Administration of a Short-Acting Anti-Angiogenic Agent.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology（2020）
Abstract
We posit that a single delivery of a short-acting anti-angiogenic agent at 1h preceding each dose of gemcitabine and other chemotherapies may be more efficacious for repeated sensitization of the ASMase pathway in multi-cycle chemotherapy regimens than current treatment strategies.
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Key words
Chemotherapy, Endothelial cells, Anti-angiogenic, ASMase, Ceramide
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