What is the optimal loading dose of broad-spectrum β-lactam antibiotics in septic patients? Results from pharmacokinetic simulation modelling
International Journal of Antimicrobial Agents(2020)
摘要
•Standard loading doses of broad-spectrum β-lactams may result in inadequate concentrations for less-susceptible pathogens.•Higher loading doses are necessary to immediately achieve adequate drug concentrations.•These drug regimens should be validated in prospective studies.
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关键词
β-Lactams,Loading dose,Pharmacokinetics,Sepsis,Monte Carlo simulation
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