Focal drug administration via heparin-containing cryogel microcarriers reduces cancer growth and metastasis.

Ben Newland,Carmine Varricchio, Yvonne Körner,Franziska Hoppe,Christian Taplan,Heike Newland,Dimitri Eigel,Giusy Tornillo,Dagmar Pette,Andrea Brancale,Petra B Welzel,F Philipp Seib,Carsten Werner

Carbohydrate Polymers（2020）

引用 17|浏览25

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摘要

•Heparin-based microcarriers load and release drugs by electrostatic attraction.•Doxorubicin preferentially binds to the heparin component of the microcarrier.•Doxorubicin release lasted 42 days.•Drug loaded microcarriers reduced breast cancer tumor growth in vivo.

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关键词

Sodium heparin CID: 22833565,N-Ethyl-N′-(3-dimethylaminopropyl)carbodiimide (EDC) CID: 15908,N-Hydroxysulfosuccinimide (NHS) sodium salt CID: 133909,Dimethyl sulfoxide (DMSO) CID: 679,Toluene (≥99.5%) CID: 1140,Poly(ethylene glycol)-block-poly(propylene glycol)-block-poly(ethylene glycol) (Synperonic® PEP105) SID: 24888568,Alexa Fluor™ 647 CID: 102227060,Doxorubicin, hydrochloride salt CID: 443939

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