Multidrug-Resistant Hospital Bacteria: Epidemiological Factors And Susceptibility Profile
MICROBIAL DRUG RESISTANCE(2021)
摘要
Increase in antimicrobial resistance to antibiotics is the product of the evolution and natural adaptation of microorganisms through mutations and genetic recombination caused by the indiscriminate use of antibiotics and the ineffective control and prevention of infection. The current study analyzes the profile of multiresistant hospital bacteria in two hospitals in Pelotas, state of Rio Grande do Sul, Brazil. Over the course of 4 months, patient's gender and age, hospital accommodation type, and sample site were evaluated. Two hundred and eighty-six microbiological culture antibiogram reports of hospitalized patients and outpatients of both sexes, between zero and 96 years of age, were analyzed. BacteriumKlebsiella pneumoniaewas the most prevalent. The most resistant Gram-negative bacilli (GNB) wereK. pneumoniae(27.5%);Acinetobacter baumannii(24.1%);Escherichia coli(14.7%); andPseudomonas aeruginosa(14.5%). The most resistant Gram-positive cocci (GPC) wereEnterococcus faecium(27.5%) andStaphylococcus aureus(25.5%). The classes of antibiotics with the greatest number of resistant GNB included penicillins (84.8%), quinolones (77.5%), and cephalosporins (75.7%). In the case of GPC, the most resistant were macrolides (95.4%); lincosamides (90.3%), and penicillins (77%). Among GNBs, polypeptides had the highest sensitivity rate (81.3%), whereas, among GPC, fusidanes, glycylcyclines, and lipopeptides had 100% sensitivity.
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关键词
hospital infection, infections related to health assistance, MDR, antibiotics, epidemiology
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