Comparative assessment of the effects of bumped kinase inhibitors on early zebrafish embryo development and pregnancy in mice

Nicoleta Anghel,Pablo A. Winzer,Dennis Imhof,Joachim Müller,Xavier Langa,Jessica Rieder,Lynn K. Barrett,Rama Subba Rao Vidadala,Wenlin Huang,Ryan Choi,Mathew A. Hulverson,Grant R. Whitman,Samuel L. Arnold,Wesley C. Van Voorhis,Kayode K. Ojo,Dustin J. Maly,Erkang Fan,Andrew Hemphill

International Journal of Antimicrobial Agents（2020）

引用 7|浏览46

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摘要

•Bumped kinase inhibitors (BKIs) prevent vertical transmission of Neospora caninum.•A zebrafish embryo development assay was established to assess direct embryotoxicity of BKIs.•BKIs that induce toxic effects in zebrafish at low concentration also affect pregnancy.•The zebrafish assay is cost effective, less time consuming, and can reduce animal use.

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关键词

Bumped kinase inhibitor,CDPK1,Apicomplexan parasite,Zebrafish,Pregnancy,Embryo development

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