Impact of the DSP-H1684R Genetic Variant on Ion Channels Activity in iPSC-Derived Cardiomyocytes.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology(2020)
Abstract
Our results show that desmoplakin genetic variants, besides conduction slowing caused by structural heart remodeling, could affect multiple ion channel activity aggravating arrhythmia manifestation in PCCD.
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Key words
Arrhythmias, Cardiomyocytes, Desmoplakin, Induced pluripotent stem cells, Ion channels, Progressive cardiac conduction disease
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