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Impact of the DSP-H1684R Genetic Variant on Ion Channels Activity in iPSC-Derived Cardiomyocytes.

Konstantin Gusev,Aleksandr Khudiakov,Anastasia Zaytseva,Kseniya Perepelina,Sofia Makeenok,Elena Kaznacheyeva,Anna Kostareva

Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology（2020）

Cited 8|Views28
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Abstract
Our results show that desmoplakin genetic variants, besides conduction slowing caused by structural heart remodeling, could affect multiple ion channel activity aggravating arrhythmia manifestation in PCCD.
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Key words
Arrhythmias, Cardiomyocytes, Desmoplakin, Induced pluripotent stem cells, Ion channels, Progressive cardiac conduction disease
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