Butylparaben multigenerational reproductive assessment by continuous breeding in Hsd:Sprague Dawley SD rats following dietary exposure

Troy D. Hubbard,Amy Brix,Chad R. Blystone,Barry S. McIntyre,Keith Shockley,Helen Cunny,Suramya Waidyanatha,Katie J. Turner,Sandra McBride,Georgia K. Roberts

Reproductive Toxicology（2020）

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摘要

•Public safety concerns of endocrine disruption by parabens have been on the rise.•Toxicity was assessed using multigenerational continuous breeding study design.•Increased liver weight and hepatic hypertrophy occurred in perinatally exposed rats.•Reproduction and pubertal development were unperturbed by butylparaben exposure.

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AGD,BPS,BP,GD,LD,LOAEL,LOEL,NOAEL,NOEL,PND,RACB,SD,VO

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