Some Features of the Tscherniac‒Einhorn Reaction with 2-Thiouracil Derivatives

I. A. Novakov,D. S. Sheikin,V. V. Chapurkin,M. B. Navrotskii,A. S. Babushkin,E. A. Ruchko, A. Yu. Maryshev,D. Schols

Russian Journal of General Chemistry（2020）

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摘要

The Tscherniac–Einhorn reaction of 6-methyl and 6-(trifluoromethyl) derivatives of 2-thiouracil with N -(bromomethyl)phthalimide in under basic catalysis leads to the formation of S -amidomethylation products. When using 6-amino-2-thiouracil, decomposition of the alkylation products occurs. An in vitro study of the compounds obtained showed their lack of cytotoxicity and anti-HIV-1/2 activity.

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Tscherniac‒Einhorn reaction,amidoalkylation,2-thiouracil derivatives,HIV-1/2

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