2-[4-(Het)aryl-2-oxopyrrolidin-1-yl]acetohydrazides: synthesis, structures, and reactions with carbonyl compounds

N. V. Gorodnicheva,O. S. Vasil’eva,E. S. Ostroglyadov,R. I. Baichurin,S. V. Makarenko,F. A. Karamov, O. A. Lodochnikova,I. A. Litvinov

Russian Chemical Bulletin（2020）

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Abstract

2-[4-(Het)aryl-2-oxopyrrolidin-1-yl]acetohydrazides, structural analogs of piracetam, were synthesized by the condensation of 2-[4-(het)aryl-2-oxopyrrolidin-1-yl]acetates with hydrazine hydrate and phenylhydrazine. New [ N′ -alkyl(hetaryl)idene]-4-(het)aryl-2-oxopyrrolidin-1-ylacetohydrazides were synthesized by the reaction of 2-[4-(het)aryl-2-oxopyrrolidin-1-yl]-acetohydrazides with aromatic aldehydes, acetone, and acetophenone.

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Key words

racetams,2-pyrrolidone,2-pyrrolidonecarbohydrazides,hydrazides,hydrazones,rotamers,molecular structure,X-ray diffraction

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