Saponins as cytotoxic agents: an update (2010–2018). Part I—steroidal saponins
Phytochemistry Reviews(2020)
Abstract
Steroidal saponins are a group of glycosides widely distributed among monocotyledonous families. They exert a wide spectrum of biological effects including cytotoxic and antitumor properties which are the most studied. This review is an update of our previous paper— Saponins as cytotoxic agents (Podolak et al. in Phytochem Rev 9:425–474, 2010) and covers studies that were since published (2010–2018). In this paper we refer to steroidal saponins presenting results of cytotoxicity studies, mechanisms of action and structure–activity relationships.
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Key words
Cytotoxicity,Steroidal glycosides,Mechanisms of action
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