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Antimycotic Activity of Naftifine Hydrochloride Solution in Combination with Poly(Ethylene Glycols)

S. I. Kosenkova,I. I. Krasnyuk,I. I. Krasnyuk Jr,A. V. Belyatskaya,O. I. Stepanova,T. Li,T. V. Fateeva,E. V. Mazyarkin,V. V. Novikov,T. V. Korochkina

Pharmaceutical Chemistry Journal（2020）

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Abstract
The microbiological activity of naftifine hydrochloride solution in combination with poly(ethylene glycols) (PEG-400 and PEG-1000) was determined and compared with that of the existing foreign drug Exoderil®. The results showed that the fungistatic activity (minimum inhibitory concentration) of the proposed solution was about double that of Exoderil solution for Candida albicans ATCC 10231.
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Key words
naftifine hydrochloride,dermatophytes,microbiology,poly(ethylene glycol)
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