Resveratrol protects against apoptosis induced by interleukin-1β in nucleus pulposus cells via activating mTOR/caspase-3 and GSK-3β/caspase-3 pathways.

Xiaohui Guo,Xiaoliang Bai,Feng Zhang,Long Zheng,Wenyuan Ding,Sidong Yang

Bioscience reports（2020）

Cited 4|Views11

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Abstract

RES can inhibit apoptosis induced by IL-1β in human NPCs. PI3K/Akt/mTOR/caspase-3 and PI3K/Akt/GSK-3β/caspase-3 pathways are potential mechanisms underlying this process.

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Key words

Apoptosis,Interleukin-1,Intervertebral disc,Nucleus pulposus cells,Resveratrol

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