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A link between metabolic energetics and pancreatic cancer mechanosensing

Maria V. Liberti,Kivanc Birsoy

NATURE METABOLISM（2020）

Cited 2|Views11
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Abstract
Extracellular-matrix remodelling contributes to tumour progression, results in intratumoural fibrosis and promotes metastatic behaviour. A new study by Papalazarou et al. now reveals that a pathway involved in ATP supply, the creatine phosphagen system, is a mechanosensitive target during pancreatic cancer invasion.
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Key words
Cancer metabolism,Extracellular matrix,Metastasis,Life Sciences,general
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