Utilization of CRISPR/Cas9 gene editing in cellular therapies for lymphoid malignancies

Maryam Mehravar,Elham Roshandel,Maryam Salimi,Rouzbeh Chegeni,Majid Gholizadeh,Mohammad Hossein Mohammadi,Abbas Hajifathali

Immunology Letters（2020）

引用 7|浏览3

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摘要

•Strategies gene editing technologies have been utilized same along for cancer immunotherapy in different studies.•The prevalence of the lymphoid cancers is increasing faster than other common cancer in the world.•The possible future therapeutic agents to treat lymphoid malignancies by using of CRISPR/Cas9 technology are here discussed.•Optimization of CRISPR/Cas9 system for mentioned applications have been overviewed.

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关键词

ALL,AML,ACT,ATLL,B2M,CAR,CLL,Cas9,Cpf1,CRISPR,CRS,CTL,GVHD,HB,HSCs,HSCT,HDR,HLA,iNKT,LAM-HTGTS,LAG-3,MN,NK,NHEJ,PD-1,PAM,RNP,SCD,SOCS3,TCR,TRAC,TRBC,TIM-3,TALENs,TGFBR2,ZFNs,GUIDE-Seq,NSG

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