Circulating Pregenomic Hepatitis B Virus Rna Is Primarily Full-Length In Chronic Hepatitis B Patients Undergoing Nucleos(T)Ide Analogue Therapy

Hepatitis B virus RNA is detectable in the serum of infected patients; however, the RNA species has been questioned. We tested 1827 specimens using a quantitative dual-target quantitative polymerase chain reaction assay and determined that full-length pregenomic RNA is the primary source. 'these results clarify the major identity of circulating HBV RNA species.