Osmotic perception of GABAergic synaptic transmission in the supraoptic nucleus of rats.

Toyoaki Ohbuchi,Takeshi Saito,Toru Yokoyama,Hirofumi Hashimoto,Takashi Maruyama,Hideaki Suzuki,Yoichi Ueta

IBRO Reports（2020）

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摘要

Extracellular osmolality plays a crucial role in controlling the activation of neurons. Hypertonic stimulation modulates glutamatergic inputs to the supraoptic nucleus (SON) magnocellular neurosecretory cells (MNCs) putative vasopressin (VP) neurons through capsaicin-insensitive transient receptor potential vanilloid (TRPV) 1 channels on the presynaptic terminals. However, it remains unclear whether osmotic stimulation modulates GABAergic inputs to VP-secreting neurons within punched-out slices containing only the SON and the perinuclear zone.

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关键词

Hypertonic condition,Hypotonic stimulation,Miniature GABAergic postsynaptic currents (mGPSCs),Supraoptic nucleus,Vasopressin neuron,Whole-cell patch-clamp

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