Simultaneous Detection Of Carbon Monoxide And Viscosity Changes In Cells
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION(2020)
摘要
A new family of robust, non-toxic, water-compatible ruthenium(II) vinyl probes allows the rapid, selective and sensitive detection of endogenous carbon monoxide (CO) in live mammalian cells under normoxic and hypoxic conditions. Uniquely, these probes incorporate a viscosity-sensitive BODIPY fluorophore that allows the measurement of microscopic viscosity in live cells via fluorescence lifetime imaging microscopy (FLIM) while also monitoring CO levels. This is the first example of a probe that can simultaneously detect CO alongside small viscosity changes in organelles of live cells.
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关键词
endogenous CO, fluorescence, ruthenium, sensing, viscosity
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