Two co(II)-based coordination polymers: photocatalytic dye degradation properties and treatment effect against colon cancer by inhibiting IL-6-STAT3 inflammatory signaling pathway

Two novel coordination polymers, formulated as {[Co 3 (tcpb) 2 (bimb)(DMF)]} n ( 1 , bimb = 1,4-bis(imidazol-1-ylmethyl)benene, DMF = N,N-dimethylformamide) and {[Co 2 (tcpb)(bim)](DMF) 3 ·(Dioxane) 2 ·(H 2 O) 3 } n ( 2 , Hbim = benzimidazole) were prepared from 1,3,5-tris(4-carbonylphenyloxy)benzene (H 3 tcpb), a semi-rigid tripodal carboxylate ligand as well as different N-donor ligands under solvothermal conditions. Due to their excellent water stability, complexes 1 and 2 could be used as catalysts for photocatalytic degradation of dye under the UV irradiation. Furthermore, the protective effect of the compound against colitis-associated colon cancer (CAC) was assessed and the particular mechanism was discussed in this study. Firstly, the real time polymerase chain reaction (PCR) was carried out to determine the il-6 and stat3 relative expression in the colon cancer cells after treated by compounds 1 and 2 . Then, the percentage of the colon cancer cells after treated by compounds 1 and 2 was detected via Annexin V-FITC/PI apoptosis assay.