Vitamin-D dysregulation in early- and late-onset preeclampsia: A gestational-age matched study

Courtney B Martin,Bryan T Oshiro, LeeAnna D Sands, Salma Kabir,Donna Thorpe, Tatiana C Clark,Ruofan Yao,Eugenia Mata-Greenwood

The Journal of Steroid Biochemistry and Molecular Biology（2020）

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摘要

•EOP showed decreased 1α,25-(OH)2-D plasma levels and placental nuclear vitamin D receptor (VDR) protein levels.•LOP showed decreased 25-OH-D levels, placental 25-hydroxylase CYP2R1, and transporter cubulin expression.•Preeclampsia endogenous dysregulation was a significant determinant of 1α,25-(OH)2-D levels in early-onset pregnancies.•Maternal BMI was a significant determinant of 25-OH-D levels in late-onset pregnancies.

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关键词

Placenta,Metabolism,Preeclampsia,Fetal growth restriction,Vitamin D metabolites

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