Ustiloxin biosynthetic machinery is not compatible between Aspergillus flavus and Ustilaginoidea virens.

Maiko Umemura,Kaoru Kuriiwa,Koichi Tamano,Yutaka Kawarabayasi

Fungal Genetics and Biology（2020）

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摘要

•Synthetic genes of ustiloxin core peptides were expressed in Aspergillus flavus.•Ustiloxin B was synthesized from the synthetic gene encoding YAIG.•Ustiloxin biosynthetic machinery is optimized for native core peptide sequences.•Hydroxyl group of Tyr in ustiloxin core peptide is indispensable for cyclization.

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关键词

ribosomally synthesized and post-translationally modified peptides (RiPPs),Secondary metabolite,Synthetic machinery,Precursor peptide,Synthetic gene,DUF3328 domain

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