Comparative Assessment of Extrapolation Methods Based on the Conventional Free Drug Hypothesis and Plasma Protein-Mediated Hepatic Uptake Theory for the Hepatic Clearance Predictions of Two Drugs Extensively Bound to Both the Albumin and Alpha-1-Acid Glycoprotein.
Journal of Pharmaceutical Sciences（2020）
Key words
Regulatory science,Biotechnology,Antibody drug(s),Formulation,Protein(s)
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