Chromosome 17q21 Snp Rs8076131 Risk Allele Associates With Airway Smooth Muscle Hypertrophy In Fatal Asthmad

Marina Miller,Peter Rosenthal,Ning Weng, Alex Pham,Gyu Young Hur,John Elliot,Francis H.Y. Green,Alan James,David H. Broide

Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology（2020）

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摘要

Airway remodeling in asthma is characterized by the presence of increased airway smooth muscle (ASM), increased mucus producing cells (submucosal mucous glands and epithelial goblet cells), and subepithelial fibrosis (deposition of collagen and extracellular matrix proteins) which all contribute to increased airway wall thickness.

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关键词

Asthma,ORMDL3,SNP rs8076131,airway smooth muscle

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