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Water-soluble amphiphilic ruthenium(ii) polypyridyl complexes as potential light-activated therapeutic agents.

Sandra Estalayo-Adrián,Salvador Blasco,Sandra A Bright,Gavin J McManus,Guillermo Orellana,D Clive Williams,John M Kelly,Thorfinnur Gunnlaugsson

CHEMICAL COMMUNICATIONS（2020）

Cited 16|Views40
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Abstract
Two water-soluble amphiphilic Ru(ii) polypyridyl complexes containingN-1,10-phenanthrolin-5-yldocosanamide and 1,10-phenanthroline (phen) or 1,4,5,8-tetraazaphenanthrene (TAP) as ligands were synthesised and their photophysical and photobiological properties evaluated; both complexes showed a rapid cellular uptake and displayed phototoxicity against HeLa cervical cancer cells.
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Key words
polypyridyl complexes,water-soluble,light-activated
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