The role of factor H-related proteins FHR-1 , FHR-3 and FHR-5 in the regulation of the complement system

s: Csincsi ÁI, Geisbrecht BV, Józsi M. The C3-binding domain of staphylococcal extracellular fibrinogen-binding protein affects interaction of C3b with human factor H-related protein 4 and inhibits C3 convertase formation. Mol Immunol 2014 61:55-56. Weiszhár Z, Cserhalmi M, Csincsi ÁI, Lázár J, Takács L, Józsi M. Novel monoclonal antibodies against human factor H allow mapping of functional domains and binding sites of autoantibodies. Mol Immunol 2015 67:191. Csincsi ÁI, Pouw RB, Tortajada A, de Córdoba SR, Wouters D, Józsi M. Factor H-related protein 3 (FHR-3) inhibits factor H binding to pentraxins and malondialdehyde epitopes, and activates the alternative pathway via C3b binding. Immunobiology 2016 10:1177. Kárpáti É, Cserhalmi M, Csincsi ÁI, Hajnal D, Papp A, Uzonyi B, Józsi M. Interaction of factor H family proteins with DNA and dead cells: Implications for the regulation of opsonization. Mol Immunol 2017 89:140-141. Papp A, Cserhalmi M, Csincsi ÁI, Uzonyi B, Ermert D, Blom AM, Józsi M. Mapping of ligand binding sites provides insight into the function of factor H-related protein 5. Mol Immunol 2017 89:145.