Outcomes and Prognostic Factors for Non-metastatic Osteosarcoma of the Extremity

Until the 1970s, osteosarcoma had a very poor prognosis, but major progress in outcomes followed the introduction of adjuvant chemotherapy, with disease-free survival rates increasing from below 20% with surgery alone to more than 40% with adjuvant chemotherapy [1-3]. Nevertheless, recurrent disease still occurs in approximately 30%-40% of patients and more than 70% of these patients die despite second-line treatment.